Research workbench
Structure of human GEMIN6/GEMIN7/GEMIN8 trimeric complex
Analyse Structure of human GEMIN6/GEMIN7/GEMIN8 trimeric complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BBL
- Type
- protein
- Length
- 418 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gem-associated protein 6; Gem-associated protein 7; Gem-associated protein 8
- UniProt
- Q8WXD5, Q9H840, Q9NWZ8
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 5 distinct chains · 41% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Gem-associated protein 6 | protein | 85 | 22% helix, 42% strand | Q8WXD5 |
| D | Gem-associated protein 7 | protein | 87 | 31% helix, 43% strand | Q9H840 |
| E | Gem-associated protein 8 | protein | 39 | 79% helix, 0% strand | Q9NWZ8 |
| B | Gem-associated protein 7 | protein | 85 | 32% helix, 41% strand | Q9H840 |
| F | Gem-associated protein 8 | protein | 37 | 86% helix, 0% strand | Q9NWZ8 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.34 | 0.76 | 13 | empty |
| 2 | 54 | 0.30 | 0.75 | 11 | empty |
Interfaces
7 interfaces between chains.
- A–B · 1329 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 1328 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 802 Ų buried · 7 hydrogen bonds · protein-protein
- A–F · 433 Ų buried · 6 hydrogen bonds · protein-protein
- B–F · 122 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7BBL · Structure of human Gemin6/Gemin7/Gemin8 trimeric complex · the same entry in another collection · chain F against F, TM-score 1.00
- Q9H840 · AlphaFold monomer V2.0 prediction for gem-associated protein 7 (Q9H840) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q8WXD5 · AlphaFold monomer V2.0 prediction for gem-associated protein 6 (Q8WXD5) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9NWZ8 · AlphaFold monomer V2.0 prediction for gem-associated protein 8 (Q9NWZ8) · a predicted model of the same protein · chain E against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WXD5
- Every structure of UniProt Q9H840
- Every structure of UniProt Q9NWZ8
- Elsewhere: RCSB PDB 7BBL · PDBe 7BBL · UniProt Q8WXD5 · UniProt Q9H840 · UniProt Q9NWZ8
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