MolNFT v1 · #173772 · protein + RNA

Structure of rig-I ctd (I875A) bound to P-RNA

7BAI · Antiviral innate immune response receptor rig-I: “Structure of rig-I ctd (I875A) bound to P-RNA”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.70). MolNFT v1 #173772 on GenesisL1: 3D structure, binding sites and…

PDB: 7BAI
Type: protein + RNA
Length: 396 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antiviral innate immune response receptor rig-I; RNA…
EC: 3.6.4.13
UniProt: O95786
Ligands: ZN
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 4 distinct chains · 12% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Antiviral innate immune response receptor rig-I (EC 3.6.4.13)	protein	120	13% helix, 50% strand	O95786
B	Antiviral innate immune response receptor rig-I (EC 3.6.4.13)	protein	121	11% helix, 46% strand	O95786
C, D, V	RNA (5'-R((GDP)PAPCPGPCPUPAPGPCPGPUPC)-3')	rna	12	—	—
E	Antiviral innate immune response receptor rig-I (EC 3.6.4.13)	protein	119	13% helix, 51% strand	O95786

Ligands and binding sites

ZN · Zinc ion · metal · 5 copies · chains A, B, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	777	0.70	0.77	46	empty
2	496	0.67	0.78	47	empty
3	253	0.54	0.76	24	empty

Interfaces

10 interfaces between chains.

C–D · 541 Å² buried · 38 hydrogen bonds · nucleic-nucleic
E–V · 436 Å² buried · 10 hydrogen bonds · protein-nucleic
A–C · 426 Å² buried · 6 hydrogen bonds · protein-nucleic
B–D · 411 Å² buried · 8 hydrogen bonds · protein-nucleic
B–E · 339 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 modified (nucleotide modification).

Compared structures

7BAI · Structure of RIG-I CTD (I875A) bound to p-RNA · the same entry in another collection · chain V against V, TM-score 1.00
O95786 · AlphaFold monomer V2.0 prediction for antiviral innate immune response receptor rig-I… · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95786
Elsewhere: RCSB PDB 7BAI · PDBe 7BAI · UniProt O95786

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