MolNFT v1 · #173771 · protein + RNA

Structure of rig-I ctd bound to oh-RNA

7BAH · Antiviral innate immune response receptor rig-I: “Structure of rig-I ctd bound to oh-RNA”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.71). MolNFT v1 #173771 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7BAH
Type: protein + RNA
Length: 267 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antiviral innate immune response receptor rig-I; RNA…
EC: 3.6.4.13
UniProt: O95786
Ligands: ZN
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 11% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Antiviral innate immune response receptor rig-I (EC 3.6.4.13)	protein	121	10% helix, 46% strand	O95786
B	Antiviral innate immune response receptor rig-I (EC 3.6.4.13)	protein	122	12% helix, 50% strand	O95786
C, D	RNA (5'-R(GPAPCPGPCPUPAPGPCPGPUPC)-3')	rna	12	—	—

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	995	0.71	0.76	52	empty

Interfaces

5 interfaces between chains.

C–D · 563 Å² buried · 68 hydrogen bonds · nucleic-nucleic
B–D · 351 Å² buried · 1 hydrogen bond · protein-nucleic
A–C · 340 Å² buried · 2 hydrogen bonds · protein-nucleic
A–D · 152 Å² buried · 1 hydrogen bond · protein-nucleic
B–C · 130 Å² buried · 3 hydrogen bonds · protein-nucleic

Compared structures

7BAH · Structure of RIG-I CTD bound to OH-RNA · the same entry in another collection · chain A against A, TM-score 1.00
O95786 · AlphaFold monomer V2.0 prediction for antiviral innate immune response receptor rig-I… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95786
Elsewhere: RCSB PDB 7BAH · PDBe 7BAH · UniProt O95786

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