MolNFT v1 · #173584 · protein + DNA
Structural basis of reactivation of oncogenic P53 mutants by a small molecule: methylene quinuclidinone (mq). human P53DBD-R282W mutant bound to DNA and mq: R282W-DNA-mq
7B4E: “Structural basis of reactivation of oncogenic P53 mutants by a small molecule: methylene quinuclidinone (mq).…”. X-ray diffraction, 3 ligands (QN8, QNN, ZN). MolNFT v1 #173584 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7B4E
- Type
- protein + DNA
- Length
- 200 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P04637
- Ligands
- QN8, QNN, ZN
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 190 | — | P04637 |
| B | — | dna | 10 | — | — |
Ligands and binding sites
- QN8 · (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one · ligand · 3 copies · chains A, B
- QNN · (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one · ligand · chains A, B
- ZN · Zinc ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7B4E · Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 7B4E · PDBe 7B4E · UniProt P04637
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