MolNFT v1 · #173424 · protein

Structure of DDR2 ds domain in complex with vhh

7AZB · Discoidin domain-containing receptor 2: “Structure of DDR2 ds domain in complex with vhh”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #173424 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7AZB
Type: protein
Length: 272 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Discoidin domain-containing receptor 2; Vhh
EC: 2.7.10.1
UniProt: Q16832
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Discoidin domain-containing receptor 2 (EC 2.7.10.1)	protein	160	6% helix, 42% strand	Q16832
B	Vhh	protein	112	8% helix, 45% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.35	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 806 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7AZB · Structure of DDR2 DS domain in complex with VHH · the same entry in another collection · chain A against A, TM-score 1.00
Q16832 · AlphaFold monomer V2.0 prediction for discoidin domain-containing receptor 2 (Q16832) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16832
Elsewhere: RCSB PDB 7AZB · PDBe 7AZB · UniProt Q16832

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