UniProt Q16832
Discoidin domain-containing receptor 2 (Q16832)
Discoidin domain-containing receptor 2 (UniProt Q16832), EC 2.7.10.1: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q16832
- Protein
- Discoidin domain-containing receptor 2
- EC
- 2.7.10.1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 23 · 2 records with a druggable one
Structures
11 records of Q16832 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WUH | Crystal structure of the DDR2 discoidin domain bound to a triple- helical collagen peptide | x-ray diffraction | A | — | — |
| 2WUH | Crystal structure of the DDR2 discoidin domain bound to a triple-helical collagen peptide | x-ray diffraction | A | — | — |
| 2Z4F | Solution structure of the Discoidin Domain of DDR2 | solution nmr | A | — | — |
| 2Z4F | Solution structure of the discoidin domain of DDR2 | solution nmr | A | — | — |
| 6FER | Crystal Structure of human DDR2 kinase in complex with… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | D6Q | 20 (best 0.79) |
| 6FER | Crystal structure of human DDR2 kinase in complex with 2-[4,5… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | D6Q | — |
| 7AYM | Structure of DDR2 Kinase domain in complex with IBZ3 | x-ray diffraction | A | 4VD | 2 (best 0.74) |
| 7AYM | Structure of DDR2 kinase domain in complex with IBZ3 | x-ray diffraction | A | 4VD | — |
| 7AZB | Structure of DDR2 DS domain in complex with VHH | x-ray diffraction | A | — | 1 (best 0.35) |
| 7AZB | Structure of DDR2 ds domain in complex with vhh | x-ray diffraction | A | — | — |
| Q16832 | AlphaFold monomer V2.0 prediction for discoidin domain-containing receptor 2 (Q16832) | predicted | A | — | — |
Ligands
- 4VD · N-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide · in 2 records
- D6Q · 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl) ethyl]ethanamide · in 2 records
Experiment against prediction
- 2WUH chain A against the predicted model Q16832: TM-score 0.99, RMSD 0.48 Å
- 2WUH chain A against the predicted model Q16832: TM-score 0.99, RMSD 0.48 Å
- 7AZB chain A against the predicted model Q16832: TM-score 0.99, RMSD 0.50 Å
- 7AZB chain A against the predicted model Q16832: TM-score 0.99, RMSD 0.50 Å
- 7AYM chain A against the predicted model Q08345: TM-score 0.97, RMSD 1.27 Å
- 7AYM chain A against the predicted model Q08345: TM-score 0.97, RMSD 1.27 Å
- 6FER chain J against the predicted model Q16832: TM-score 0.97, RMSD 1.28 Å
- 6FER chain J against the predicted model Q16832: TM-score 0.97, RMSD 1.28 Å
- 6FER chain I against the predicted model Q16832: TM-score 0.97, RMSD 1.28 Å
- 6FER chain I against the predicted model Q16832: TM-score 0.97, RMSD 1.28 Å
Elsewhere
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