MolNFT v1 · #173332 · protein

Crystal structure of peroxisome proliferator-activated receptor gamma (PPARG)IN complex with garcinoic acid

7AWD: “Crystal structure of peroxisome proliferator-activated receptor gamma (PPARG)IN complex with garcinoic acid”. X-ray diffraction, 1 ligand (NQD), 1 pocket (best druggability 0.82). MolNFT v1 #173332 on GenesisL1: 3D structure…

PDB: 7AWD
Type: protein
Length: 272 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma
UniProt: P37231
Ligands: NQD
Pockets: 1 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	272	65% helix, 5% strand	P37231

Ligands and binding sites

NQD · (2Z,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-1-benzopyran-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid · ligand · 2 copies · chains A
GOL · Glycerol · additive · 3 copies · chains A
CIT · Citric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	661	0.82	0.86	55	NQD

Compared structures

7AWD · Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 7AWD · PDBe 7AWD · UniProt P37231

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.