MolNFT v1 · #173319 · protein
Mertk kinase domain in complex with a bisaminopyrimidine inhibitor
7AVZ: “Mertk kinase domain in complex with a bisaminopyrimidine inhibitor”. X-ray diffraction, 1 ligand (S4N). MolNFT v1 #173319 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7AVZ
- Type
- protein
- Length
- 268 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q12866
- Ligands
- S4N
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 268 | — | Q12866 |
Ligands and binding sites
- S4N · (R)-N2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-5-(3-methylpiperazin-1-yl)-N4-(tetrahydro-2H-pyran-4-yl)pyrimidine-2,4-diamine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7AVZ · MerTK kinase domain in complex with a bisaminopyrimidine inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- Q12866 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase mer (Q12866) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12866
- Elsewhere: RCSB PDB 7AVZ · PDBe 7AVZ · UniProt Q12866
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