MolNFT v1 · #173311 · protein
Crystal structure of haspin in complex with disubstituted IMIDAZO[1,2- B]PYRIDAZINE inhibitor (compound 12)
7AVQ: “Crystal structure of haspin in complex with disubstituted IMIDAZO[1,2- B]PYRIDAZINE inhibitor (compound 12)”. X-ray diffraction, 2 ligands (S1Z, NA). MolNFT v1 #173311 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7AVQ
- Type
- protein
- Length
- 328 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q8TF76
- Ligands
- S1Z, NA
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 328 | — | Q8TF76 |
Ligands and binding sites
- S1Z · (2~{R})-2-[[3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol · ligand · chains A
- NA · Sodium ion · metal · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7AVQ · Crystal structure of haspin in complex with disubstituted imidazo[1,2- b]pyridazine… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TF76 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase haspin (Q8TF76) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TF76
- Elsewhere: RCSB PDB 7AVQ · PDBe 7AVQ · UniProt Q8TF76
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.