MolNFT v1 · #173216 · protein
Orotidine 5'-monophosphate decarboxylase-domain of human umps in complex with the reaction product ump at 0.95 ångström resolution
7ASQ · Uridine 5'-monophosphate synthase: “Orotidine 5'-monophosphate decarboxylase-domain of human umps in complex with the reaction product ump at…”. X-ray diffraction, 3 ligands (U5P, NA, SO4), 1 pocket (best druggability 0.50). MolNFT…
- PDB
- 7ASQ
- Type
- protein
- Length
- 256 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uridine 5'-monophosphate synthase
- EC
- 2.4.2.10, 4.1.1.23
- UniProt
- P11172
- Ligands
- U5P, NA, SO4
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uridine 5'-monophosphate synthase (EC 2.4.2.10, 4.1.1.23) | protein | 256 | 44% helix, 17% strand | P11172 |
Ligands and binding sites
- U5P · Uridine-5'-monophosphate · ligand · chains A
- NA · Sodium ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.50 | 0.78 | 28 | U5P |
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 7ASQ · Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11172
- Elsewhere: RCSB PDB 7ASQ · PDBe 7ASQ · UniProt P11172
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