MolNFT v1 · #173212 · protein
43S preinitiation complex from trypanosoma cruzi with the KDDX60 helicase bound with ATP
7ASK: “43S preinitiation complex from trypanosoma cruzi with the KDDX60 helicase bound with ATP”. Electron microscopy, 2 ligands (ADP, MG), 20 pockets (best druggability 0.81). MolNFT v1 #173212 on GenesisL1: 3D structure, binding sites…
- PDB
- 7ASK
- Type
- protein
- Length
- 1,523 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KDDX60
- UniProt
- Q4E5Z1
- Ligands
- ADP, MG
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 40% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | KDDX60 | protein | 1523 | 40% helix, 5% strand | Q4E5Z1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.81 | 0.95 | 40 | empty |
| 2 | 754 | 0.78 | 0.82 | 77 | MG, ADP |
| 3 | 1077 | 0.77 | 0.80 | 103 | empty |
| 4 | 636 | 0.74 | 0.80 | 77 | empty |
| 5 | 509 | 0.74 | 0.82 | 61 | empty |
Compared structures
- 7ASK · 43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase bound with ATP · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4E5Z1
- Elsewhere: RCSB PDB 7ASK · PDBe 7ASK · UniProt Q4E5Z1
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