MolNFT v1 · #173119 · protein
Structure of the human tho - UAP56 complex
7APK · Tho complex subunit 1: “Structure of the human tho - UAP56 complex”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #173119 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7APK
- Type
- protein
- Length
- 9,967 residues
- Chains
- 30
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tho complex subunit 1; Tho complex subunit 2; Tho complex subunit 3; Tho complex subunit…
- EC
- 3.6.4.13
- UniProt
- Q96FV9, Q8NI27, Q96J01, Q13769, Q86W42, Q6I9Y2, Q13838
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 14 distinct chains · 55% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, a | Tho complex subunit 1 | protein | 266 | 75% helix, 0% strand | Q96FV9 |
| B, b | Tho complex subunit 2 | protein | 706 | 77% helix, 0% strand | Q8NI27 |
| C, K, c, k | Tho complex subunit 3 | protein | 304 | 4% helix, 51% strand | Q96J01 |
| E | Tho complex subunit 5 homolog | protein | 523 | 52% helix, 15% strand | Q13769 |
| F, N, n | Tho complex subunit 6 homolog | protein | 337 | 7% helix, 44% strand | Q86W42 |
| G, g | Tho complex subunit 7 homolog | protein | 153 | 96% helix, 0% strand | Q6I9Y2 |
| H, P, h, p | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) | protein | 170 | 34% helix, 21% strand | Q13838 |
| I, i | Tho complex subunit 1 | protein | 275 | 72% helix, 0% strand | Q96FV9 |
| J, j | Tho complex subunit 2 | protein | 707 | 78% helix, 0% strand | Q8NI27 |
| M, m | Tho complex subunit 5 homolog | protein | 549 | 54% helix, 14% strand | Q13769 |
| O, o | Tho complex subunit 7 homolog | protein | 155 | 94% helix, 0% strand | Q6I9Y2 |
| X, x | THOC2 anchor (putative) | protein | 37 | 89% helix, 0% strand | — |
| e | Tho complex subunit 5 homolog | protein | 512 | 54% helix, 15% strand | Q13769 |
| f | Tho complex subunit 6 homolog | protein | 329 | 7% helix, 45% strand | Q86W42 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 994 | 0.81 | 0.82 | 80 | empty |
| 2 | 995 | 0.81 | 0.82 | 71 | empty |
| 3 | 820 | 0.79 | 0.82 | 53 | empty |
| 4 | 847 | 0.79 | 0.82 | 56 | empty |
| 5 | 812 | 0.79 | 0.82 | 52 | empty |
Interfaces
53 interfaces between chains.
- m–o · 3325 Ų buried · 12 hydrogen bonds · protein-protein
- M–O · 3268 Ų buried · 12 hydrogen bonds · protein-protein
- I–J · 1963 Ų buried · 13 hydrogen bonds · protein-protein
- i–j · 1886 Ų buried · 13 hydrogen bonds · protein-protein
- a–b · 1876 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7APK · Structure of the human THO - UAP56 complex · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96FV9
- Every structure of UniProt Q8NI27
- Every structure of UniProt Q96J01
- Every structure of UniProt Q13769
- Every structure of UniProt Q86W42
- Every structure of UniProt Q6I9Y2
- Every structure of UniProt Q13838
- Elsewhere: RCSB PDB 7APK · PDBe 7APK · UniProt Q96FV9 · UniProt Q8NI27 · UniProt Q96J01 · UniProt Q13769 · UniProt Q86W42 · UniProt Q6I9Y2 · UniProt Q13838
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