MolNFT v1 · #173021 · protein
Structure of drosophila serrate C2-dsl-EGF1-EGF2
7ALT · Protein serrate: “Structure of drosophila serrate C2-dsl-EGF1-EGF2”. X-ray diffraction, 2 ligands (NAG, CA), 3 pockets (best druggability 0.39). MolNFT v1 #173021 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ALT
- Type
- protein
- Length
- 535 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein serrate
- UniProt
- P18168
- Ligands
- NAG, CA
- Pockets
- 3 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein serrate | protein | 270 | 6% helix, 39% strand | P18168 |
| B | Protein serrate | protein | 265 | 4% helix, 40% strand | P18168 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.39 | 0.73 | 20 | empty |
| 2 | 89 | 0.39 | 0.77 | 19 | empty |
| 3 | 60 | 0.33 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 815 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18168
- Elsewhere: RCSB PDB 7ALT · PDBe 7ALT · UniProt P18168
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