MolNFT v1 · #173017 · protein
Severe fever with thrombocytopenia syndrome virus (phenuiviridae) L protein
7ALP · Replicase: “Severe fever with thrombocytopenia syndrome virus (phenuiviridae) L protein”. Electron microscopy, 1 ligand (MG), 20 pockets (best druggability 0.85). MolNFT v1 #173017 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7ALP
- Type
- protein
- Length
- 1,935 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replicase
- EC
- 2.7.7.48
- UniProt
- I0DF35
- Ligands
- MG
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 40% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| U | Replicase (EC 2.7.7.48) | protein | 1935 | 40% helix, 10% strand | I0DF35 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains U
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 981 | 0.85 | 0.86 | 111 | empty |
| 2 | 892 | 0.81 | 0.84 | 81 | empty |
| 3 | 833 | 0.78 | 0.82 | 69 | empty |
| 4 | 585 | 0.78 | 0.84 | 60 | empty |
| 5 | 859 | 0.76 | 0.79 | 73 | empty |
Compared structures
- 7ALP · Severe fever with thrombocytopenia syndrome virus (Phenuiviridae) L protein · the same entry in another collection · chain U against U, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I0DF35
- Elsewhere: RCSB PDB 7ALP · PDBe 7ALP · UniProt I0DF35
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