Research workbench

Severe fever with thrombocytopenia syndrome virus (phenuiviridae) L protein

Analyse Severe fever with thrombocytopenia syndrome virus (phenuiviridae) L protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7ALP
Type: protein
Length: 1,935 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replicase
EC: 2.7.7.48
UniProt: I0DF35
Ligands: MG
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 40% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U	Replicase (EC 2.7.7.48)	protein	1935	40% helix, 10% strand	I0DF35

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains U

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	981	0.85	0.86	111	empty
2	892	0.81	0.84	81	empty
3	833	0.78	0.82	69	empty
4	585	0.78	0.84	60	empty
5	859	0.76	0.79	73	empty

Compared structures

7ALP · Severe fever with thrombocytopenia syndrome virus (Phenuiviridae) L protein · the same entry in another collection · chain U against U, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I0DF35
Elsewhere: RCSB PDB 7ALP · PDBe 7ALP · UniProt I0DF35

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