MolNFT v1 · #172853 · protein
Crystal structure of sf kinase yihv from E. COLI in complex with sulfofructose (sf), ADP-mg
7AG6 · Sulfofructose kinase: “Crystal structure of sf kinase yihv from E. COLI in complex with sulfofructose (sf), ADP-mg”. X-ray diffraction, 3 ligands (ADP, RB8, MG), 5 pockets (best druggability 0.75). MolNFT v1 #172853 on GenesisL1: 3D…
- PDB
- 7AG6
- Type
- protein
- Length
- 600 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sulfofructose kinase
- EC
- 2.7.1.184
- UniProt
- P32143
- Ligands
- ADP, RB8, MG
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sulfofructose kinase (EC 2.7.1.184) | protein | 302 | 37% helix, 26% strand | P32143 |
| B | Sulfofructose kinase (EC 2.7.1.184) | protein | 298 | 36% helix, 27% strand | P32143 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- RB8 · 6-deoxy-6-sulfo-D-fructose · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 363 | 0.75 | 0.86 | 53 | ADP, RB8, MG |
| 2 | 385 | 0.74 | 0.85 | 54 | ADP, RB8, MG |
| 3 | 174 | 0.45 | 0.75 | 31 | empty |
| 4 | 89 | 0.39 | 0.77 | 21 | empty |
| 5 | 98 | 0.37 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1477 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 7AG6 · Crystal structure of SF kinase YihV from E. coli in complex with sulfofructose (SF)… · the same entry in another collection · chain A against A, TM-score 1.00
- P32143 · AlphaFold monomer V2.0 prediction for sulfofructose kinase (P32143) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32143
- Elsewhere: RCSB PDB 7AG6 · PDBe 7AG6 · UniProt P32143
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.