MolNFT v1 · #172786 · protein
Three-dimensional structure of isonicotinimidylated liver alcohol dehydrogenase
7ADH: “Three-dimensional structure of isonicotinimidylated liver alcohol dehydrogenase”. X-ray diffraction, 2 ligands (NTN, ZN), 1 pocket (best druggability 0.69). MolNFT v1 #172786 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7ADH
- Type
- protein
- Length
- 374 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isonicotinimidylated liver alcohol dehydrogenase
- EC
- 1.1.1.1
- UniProt
- P00327
- Ligands
- NTN, ZN
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 21% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isonicotinimidylated liver alcohol dehydrogenase (EC 1.1.1.1) | protein | 374 | 21% helix, 19% strand | P00327 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 488 | 0.69 | 0.79 | 51 | NTN |
Modifications
Observed in the structure: 23 covalent (covalent ligand).
Compared structures
- 7ADH · Three-dimensional structure of isonicotinimidylated liver alcohol dehydrogenase · the same entry in another collection · chain A against A, TM-score 1.00
- P00327 · AlphaFold monomer V2.0 prediction for alcohol dehydrogenase E chain (P00327) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00327
- Elsewhere: RCSB PDB 7ADH · PDBe 7ADH · UniProt P00327
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