UniProt P00327
Alcohol dehydrogenase E chain (P00327)
Alcohol dehydrogenase E chain (UniProt P00327), EC 1.1.1.1: 178 experimental structures and 1 predicted model on GenesisL1, 21 ligands bound, 160 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P00327
- Protein
- Alcohol dehydrogenase E chain
- EC
- 1.1.1.1
- Experimental structures
- 178
- Predicted models
- 1
- Ligands
- 21
- Pockets
- 160 · 46 records with a druggable one
Structures
179 records of P00327 in the MolNFT archive: 178 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A71 | Ternary complex of an active site double mutant of horse liver alcohol dehydrogenase, PHE93=>TRP… | x-ray diffraction | A, B | — | — |
| 1A71 | Ternary complex of an active site double mutant of horse liver alcohol dehydrogenase, PHE93=>TRP… | x-ray diffraction | A, B | — | — |
| 1A72 | An active-site double mutant (PHE93->TRP, VAL203->ala) of horse liver alcohol dehydrogenase in… | x-ray diffraction | A | — | — |
| 1A72 | An active-site double mutant (PHE93->TRP, VAL203->ala) of horse liver alcohol dehydrogenase in… | x-ray diffraction | A | — | — |
| 1ADB | Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and… | x-ray diffraction | A, B | — | — |
| 1ADB | Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and… | x-ray diffraction | A, B | — | — |
| 1ADC | Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and… | x-ray diffraction | A, B | — | — |
| 1ADC | Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and… | x-ray diffraction | A, B | — | — |
| 1ADF | Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide… | x-ray diffraction | A | — | — |
| 1ADF | Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide… | x-ray diffraction | A | — | — |
| 1ADG | Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide… | x-ray diffraction | A | — | — |
| 1ADG | Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide… | x-ray diffraction | A | — | — |
| 1AXE | Crystal structure of the active-site mutant PHE93->TRP of horse liver alcohol dehydrogenase in… | x-ray diffraction | A, B | — | — |
| 1AXE | Crystal structure of the active-site mutant PHE93->TRP of horse liver alcohol dehydrogenase in… | x-ray diffraction | A, B | — | — |
| 1AXG | Crystal structure of the VAL203->ala mutant of liver alcohol dehydrogenase complexed with cofactor… | x-ray diffraction | A, B, C, D | — | — |
| 1AXG | Crystal structure of the VAL203->ala mutant of liver alcohol dehydrogenase complexed with cofactor… | x-ray diffraction | A, B, C, D | — | — |
| 1BTO | Horse liver alcohol dehydrogenase complexed to NADH and (1S,3R)3-butylthiolane 1-oxide | x-ray diffraction | A, B, C, D | — | — |
| 1BTO | Horse liver alcohol dehydrogenase complexed to NADH and (1S, 3R)3-butylthiolane 1-oxide | x-ray diffraction | A, B, C, D | — | — |
| 1HET | atomic X-ray structure of liver alcohol dehydrogenase containing a hydroxide adduct to NADH | x-ray diffraction | A, B | — | — |
| 1HET | Atomic X-ray structure of liver alcohol dehydrogenase containing a hydroxide adduct to NADH | x-ray diffraction | A, B | — | — |
| 1HEU | ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING Cadmium and a hydroxide adduct to… | x-ray diffraction | A, B | — | — |
| 1HEU | Atomic X-ray structure of liver alcohol dehydrogenase containing cadmium and a hydroxide adduct to… | x-ray diffraction | A, B | — | — |
| 1HF3 | ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING Cadmium and a hydroxide adduct to… | x-ray diffraction | A, B | — | — |
| 1HF3 | Atomic X-ray structure of liver alcohol dehydrogenase containing cadmium and a hydroxide adduct to… | x-ray diffraction | A, B | — | — |
| 1HLD | Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols | x-ray diffraction | A, B | — | — |
| 1HLD | Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols | x-ray diffraction | A, B | — | — |
| 1JU9 | Horse liver alcohol dehydrogenase VAL292SER mutant | x-ray diffraction | A, B | — | — |
| 1JU9 | Horse liver alcohol dehydrogenase VAL292SER mutant | x-ray diffraction | A, B | — | — |
| 1LDE | Horse liver alcohol dehydrogenase complexed to NADH and N-formyl piperdine | x-ray diffraction | A, B, C, D | — | — |
| 1LDE | Horse liver alcohol dehydrogenase complexed to NADH and N-formyl piperdine | x-ray diffraction | A, B, C, D | — | — |
| 1LDY | Horse liver alcohol dehydrogenase complexed to NADH and cyclohexyl formamide (cxf) | x-ray diffraction | A, B, C, D | — | — |
| 1LDY | Horse liver alcohol dehydrogenase complexed to NADH and cyclohexyl formamide (cxf) | x-ray diffraction | A, B, C, D | — | — |
| 1MG0 | Horse Liver Alcohol Dehydrogenase Complexed With NAD+ and 2,3-Difluorobenzyl Alcohol | x-ray diffraction | A, B, C, D | — | — |
| 1MG0 | Horse liver alcohol dehydrogenase complexed with NAD+ and 2, 3-difluorobenzyl alcohol | x-ray diffraction | A, B, C, D | — | — |
| 1MGO | Horse Liver Alcohol Dehydrogenase Phe93Ala Mutant | x-ray diffraction | A, B | — | — |
| 1MGO | Horse liver alcohol dehydrogenase PHE93ALA mutant | x-ray diffraction | A, B | — | — |
| 1N8K | Horse Liver Alcohol Dehydrogenase Val292Thr Mutant Complexed to NAD+ and Pyrazole | x-ray diffraction | A, B | — | — |
| 1N8K | Horse liver alcohol dehydrogenase VAL292THR mutant complexed to NAD+ and pyrazole | x-ray diffraction | A, B | — | — |
| 1N92 | Horse Liver Alcohol Dehydrogenase Complexed with NAD+ and 4-Iodopyrazole | x-ray diffraction | A, B | — | — |
| 1N92 | Horse liver alcohol dehydrogenase complexed with NAD+ and 4- iodopyrazole | x-ray diffraction | A, B | — | — |
| 1P1R | Horse liver alcohol dehydrogenase complexed with NADH and R-N-1-methylhexylformamide | x-ray diffraction | A, B, C, D | — | — |
| 1P1R | Horse liver alcohol dehydrogenase complexed with NADH and R- N-1-methylhexylformamide | x-ray diffraction | A, B, C, D | — | — |
| 1QLH | Horse liver alcohol dehydrogenase complexed to NAD double mutant of gly 293 ala and pro 295 thr | x-ray diffraction | A | — | — |
| 1QLH | Horse liver alcohol dehydrogenase complexed to NAD double mutant of gly 293 ala and pro 295 thr | x-ray diffraction | A | — | — |
| 1QLJ | Horse liver alcohol dehydrogenase apo enzyme double mutant of gly 293 ala and pro 295 thr | x-ray diffraction | A | — | — |
| 1QLJ | Horse liver alcohol dehydrogenase apo enzyme double mutant of gly 293 ala and pro 295 thr | x-ray diffraction | A | — | — |
| 1QV6 | Horse liver alcohol dehydrogenase HIS51GLN/LYS228ARG mutant complexed with NAD+ and… | x-ray diffraction | A, B | — | — |
| 1QV6 | Horse liver alcohol dehydrogenase HIS51GLN/LYS228ARG mutant complexed with NAD+ and… | x-ray diffraction | A, B | — | — |
| 1QV7 | Horse liver alcohol dehydrogenase HIS51GLN/LYS228ARG mutant complexed with NAD+ and… | x-ray diffraction | A, B | — | — |
| 1QV7 | Horse liver alcohol dehydrogenase HIS51GLN/LYS228ARG mutant complexed with NAD+ and… | x-ray diffraction | A, B | — | — |
| 1YE3 | Horse liver alcohol dehydrogenase apoenzyme | x-ray diffraction | A | — | — |
| 1YE3 | Horse liver alcohol dehydrogenase apoenzyme | x-ray diffraction | A | — | — |
| 2JHF | Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase | x-ray diffraction | A, B | — | — |
| 2JHF | Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase | x-ray diffraction | A, B | — | — |
| 2JHG | Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase | x-ray diffraction | A, B | — | — |
| 2JHG | Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase | x-ray diffraction | A, B | — | — |
| 2OHX | Refined crystal structure of liver alcohol dehydrogenase-NADH complex at 1.8 ångströms resolution | x-ray diffraction | A, B | — | — |
| 2OHX | Refined crystal structure of liver alcohol dehydrogenase-NADH complex at 1.8 ångströms resolution | x-ray diffraction | A, B | — | — |
| 2OXI | Refined crystal structure of cu-substituted alcohol dehydrogenase at 2.1 ångströms resolution | x-ray diffraction | A, B | — | — |
| 2OXI | Refined crystal structure of cu-substituted alcohol dehydrogenase at 2.1 ångströms resolution | x-ray diffraction | A, B | — | — |
119 records more on the page itself.
Ligands
- ZN · Zinc ion · in 97 records
- NAJ · Nicotinamide-adenine-dinucleotide (acidic form) · in 56 records
- PFB · 2,3,4,5,6-pentafluorobenzyl alcohol · in 34 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 23 records
- CXF · Cyclohexylformamide · in 14 records
- COD · Dephospho coenzyme A · in 4 records
- APR · Adenosine-5-diphosphoribose · in 3 records
- CO · Cobalt (II) ion · in 3 records
- NAD · Nicotinamide-adenine-dinucleotide · in 3 records
- 0BP · 2,2'-bipyridine · in 2 records
- BNF · N-benzylformamide · in 2 records
- NMH · (R)-N-(1-methyl-hexyl)-formamide · in 2 records
- NTN · Isonicotinamidine · in 2 records
- NWH · N-[(2S)-heptan-2-yl]formamide · in 2 records
- PHN · 1,10-phenanthroline · in 2 records
- VTG · (4-methylphenyl)methanol · in 2 records
- B7F · 2,2,3,3,4,4,4-heptafluorobutan-1-ol · in 1 record
- BRB · Para-bromobenzyl alcohol · in 1 record
- CD · Cadmium ion · in 1 record
- DKA · Decanoic acid · in 1 record
- PZO · Pyrazole · in 1 record
Experiment against prediction
- 6OA7 chain B against the predicted model P00327: TM-score 1.00, RMSD 0.23 Å
- 6OA7 chain B against the predicted model P00327: TM-score 1.00, RMSD 0.23 Å
- 6O91 chain B against the predicted model P00327: TM-score 1.00, RMSD 0.23 Å
- 6O91 chain B against the predicted model P00327: TM-score 1.00, RMSD 0.23 Å
- 6OWM chain B against the predicted model P00327: TM-score 1.00, RMSD 0.23 Å
- 5KCP chain B against the predicted model P00327: TM-score 1.00, RMSD 0.24 Å
- 5KCP chain B against the predicted model P00327: TM-score 1.00, RMSD 0.24 Å
- 4NG5 chain B against the predicted model P00327: TM-score 1.00, RMSD 0.24 Å
- 4NG5 chain B against the predicted model P00327: TM-score 1.00, RMSD 0.24 Å
- 5KJC chain B against the predicted model P00327: TM-score 1.00, RMSD 0.24 Å
Elsewhere
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