MolNFT v1 · #17275 · protein

P395S mutant of the P85 regulatory subunit of the N-terminal src homology 2 domain of PI3-kinase complexed to a peptide derived from pdgfr

1OO4 · Phosphatidylinositol 3-kinase regulatory alpha subunit: “P395S mutant of the P85 regulatory subunit of the N-terminal src homology 2 domain of PI3-kinase complexed to…”. Solution nmr, 1 pocket (best druggability 0.34). MolNFT v1…

PDB: 1OO4
Type: protein
Length: 119 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphatidylinositol 3-kinase regulatory alpha subunit; 8-mer peptide from pdgfr
UniProt: P23727
Pockets: 1 · best druggability 0.34

Structure

solution nmr · 2 distinct chains · 14% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphatidylinositol 3-kinase regulatory alpha subunit	protein	111	15% helix, 21% strand	P23727
B	8-mer peptide from pdgfr	protein	8	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.34	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 704 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

1OO4 · P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of… · the same entry in another collection · chain A against A, TM-score 1.00
P23727 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase regulatory subunit… · a predicted model of the same protein · chain A against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23727
Elsewhere: RCSB PDB 1OO4 · PDBe 1OO4 · UniProt P23727

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