MolNFT v1 · #172732 · protein

Structure of ppia in complex with pr dipeptide repeat

7ABT · Peptidyl-prolyl cis-trans isomerase a: “Structure of ppia in complex with pr dipeptide repeat”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #172732 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7ABT
Type: protein
Length: 171 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peptidyl-prolyl cis-trans isomerase a; Pro-arg-pro-arg-pro-arg-pro-arg
EC: 5.2.1.8
UniProt: P62937
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peptidyl-prolyl cis-trans isomerase a (EC 5.2.1.8)	protein	163	15% helix, 34% strand	P62937
B	Pro-arg-pro-arg-pro-arg-pro-arg	protein	8	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.39	0.77	23	empty

Interfaces

1 interface between chains.

A–B · 402 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

7ABT · Structure of PPIA in complex with PR dipeptide repeat · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62937
Elsewhere: RCSB PDB 7ABT · PDBe 7ABT · UniProt P62937

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