MolNFT v1 · #172655 · protein
Crystal structure of the PHE57TRP mutant of the arginine-bound form of domain 1 from tmargbp
7A99 · Amino acid ABC transporter, periplasmic amino acid-binding…: “Crystal structure of the PHE57TRP mutant of the arginine-bound form of domain 1 from tmargbp”. X-ray diffraction, 1 ligand (ARG), 1 pocket (best druggability 0.61).…
- PDB
- 7A99
- Type
- protein
- Length
- 259 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amino acid ABC transporter, periplasmic amino acid-binding PROTEIN,AMINO acid ABC…
- UniProt
- Q9WZ62
- Ligands
- ARG
- Pockets
- 1 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Amino acid ABC transporter, periplasmic amino acid-binding PROTEIN,AMINO acid ABC transporter, periplasmic amino acid-binding protein | protein | 129 | 37% helix, 22% strand | Q9WZ62 |
| B | Amino acid ABC transporter, periplasmic amino acid-binding PROTEIN,AMINO acid ABC transporter, periplasmic amino acid-binding protein | protein | 130 | 38% helix, 22% strand | Q9WZ62 |
Ligands and binding sites
- ARG · Arginine · ligand · 2 copies · chains A, B
- ACT · Acetate ion · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 455 | 0.61 | 0.75 | 56 | ARG |
Interfaces
1 interface between chains.
- A–B · 516 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7A99 · Crystal structure of the Phe57Trp mutant of the arginine-bound form of domain 1 from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZ62
- Elsewhere: RCSB PDB 7A99 · PDBe 7A99 · UniProt Q9WZ62
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