MolNFT v1 · #172570 · protein
Crystal structure of EGFR-T790M/V948R in complex with tak-788
7A6K: “Crystal structure of EGFR-T790M/V948R in complex with tak-788”. X-ray diffraction, 2 ligands (R28, SO4). MolNFT v1 #172570 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7A6K
- Type
- protein
- Length
- 1,043 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P00533
- Ligands
- R28, SO4
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 266 | — | P00533 |
| B | — | protein | 260 | — | P00533 |
| C | — | protein | 262 | — | P00533 |
| D | — | protein | 255 | — | P00533 |
Ligands and binding sites
- R28 · propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate · ligand · 4 copies · chains A, B, C, D
- SO4 · Sulfate ion · ion · 7 copies · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7A6K · Crystal Structure of EGFR-T790M/V948R in Complex with TAK-788 · the same entry in another collection · chain D against D, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 7A6K · PDBe 7A6K · UniProt P00533
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