MolNFT v1 · #172462 · protein

Crystal structure of the C-src SH3 domain mutant V111L-N113S-T114S in 3 M urea

7A37 · Proto-oncogene tyrosine-protein kinase src: “Crystal structure of the C-src SH3 domain mutant V111L-N113S-T114S in 3 M urea”. X-ray diffraction, 1 ligand (URE), 1 pocket (best druggability 0.41). MolNFT v1 #172462 on GenesisL1: 3D…

PDB: 7A37
Type: protein
Length: 120 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene tyrosine-protein kinase src
EC: 2.7.10.2
UniProt: P00523
Ligands: URE
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2)	protein	60	5% helix, 42% strand	P00523

Ligands and binding sites

URE · Urea · ligand · 9 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.41	0.75	22	URE

Interfaces

1 interface between chains.

A–B · 342 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

7A37 · Crystal structure of the c-Src SH3 domain mutant V111L-N113S-T114S in 3 M urea · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00523
Elsewhere: RCSB PDB 7A37 · PDBe 7A37 · UniProt P00523

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