MolNFT v1 · #172346 · protein
Crystal structure of the catalytic domain of corynebacterium mustelae predicted acetyltransferase acef (E2P).
6ZZM · Dihydrolipoamide acetyltransferase component of pyruvate…: “Crystal structure of the catalytic domain of corynebacterium mustelae predicted acetyltransferase acef (E2P).”. X-ray diffraction, 1 ligand (COA), 2 pockets (best…
- PDB
- 6ZZM
- Type
- protein
- Length
- 475 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- EC
- 2.3.1.-
- UniProt
- A0A0G3H170
- Ligands
- COA
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) | protein | 237 | 40% helix, 24% strand | A0A0G3H170 |
| B | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) | protein | 238 | 40% helix, 24% strand | A0A0G3H170 |
Ligands and binding sites
- COA · Coenzyme A · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 410 | 0.63 | 0.77 | 55 | COA |
| 2 | 308 | 0.60 | 0.78 | 49 | COA |
Compared structures
- 6ZZM · Crystal structure of the catalytic domain of Corynebacterium mustelae predicted… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0G3H170
- Elsewhere: RCSB PDB 6ZZM · PDBe 6ZZM · UniProt A0A0G3H170 · AlphaFold DB A0A0G3H170
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