MolNFT v1 · #172298 · protein + DNA
Cryo-EM structure of the human topoisomerase II alpha DNA- BINDING/CLEAVAGE domain in state 1
6ZY5: “Cryo-EM structure of the human topoisomerase II alpha DNA- BINDING/CLEAVAGE domain in state 1”. Electron microscopy, 1 ligand (EVP). MolNFT v1 #172298 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZY5
- Type
- protein + DNA
- Length
- 1,580 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P11388
- Ligands
- EVP
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | — | protein | 760 | — | P11388 |
| D, F | — | dna | 17 | — | — |
| E, C | — | dna | 13 | — | — |
Ligands and binding sites
- EVP · (5s,5ar,8ar,9r)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5A,6,8,8A,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside · ligand · 2 copies · chains B, D, F, C, A, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6ZY5 · Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in… · the same entry in another collection · chain E against E, TM-score 1.00
- P11388 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (P11388) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11388
- Elsewhere: RCSB PDB 6ZY5 · PDBe 6ZY5 · UniProt P11388
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