MolNFT v1 · #172116 · protein
Two-protofilament amyloid structure of S20G variant of human amylin (iapp - islet amyloid polypeptide)
6ZRQ: “Two-protofilament amyloid structure of S20G variant of human amylin (iapp - islet amyloid polypeptide)”. Electron microscopy, 1 pocket (best druggability 0.69). MolNFT v1 #172116 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6ZRQ
- Type
- protein
- Length
- 276 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Islet amyloid polypeptide
- UniProt
- P10997
- Pockets
- 1 · best druggability 0.69
Structure
electron microscopy · 1 distinct chain · 0% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Islet amyloid polypeptide | protein | 23 | 0% helix, 35% strand | P10997 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.69 | 0.84 | 39 | empty |
Interfaces
21 interfaces between chains.
- I–K · 877 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 875 Ų buried · 23 hydrogen bonds · protein-protein
- J–L · 873 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 872 Ų buried · 23 hydrogen bonds · protein-protein
- G–I · 870 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (nonstandard).
Compared structures
- 6ZRQ · two-protofilament amyloid structure of S20G variant of human amylin (IAPP - islet amyloid… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10997
- Elsewhere: RCSB PDB 6ZRQ · PDBe 6ZRQ · UniProt P10997
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