MolNFT v1 · #171962 · protein

Crystal structure of human gfat-1 R203H

6ZMJ · Glutamine--fructose-6-phosphate aminotransferase…: “Crystal structure of human gfat-1 R203H”. X-ray diffraction, 2 ligands (G6Q, GLU), 13 pockets (best druggability 0.87). MolNFT v1 #171962 on GenesisL1: 3D structure, binding sites…

PDB: 6ZMJ
Type: protein
Length: 1,298 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
EC: 2.6.1.16
UniProt: Q06210
Ligands: G6Q, GLU
Pockets: 13 · best druggability 0.87

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16)	protein	649	39% helix, 25% strand	Q06210
B	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16)	protein	649	39% helix, 23% strand	Q06210

Ligands and binding sites

G6Q · Glucose-6-phosphate · ligand · 2 copies · chains A, B
GLU · Glutamic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	643	0.87	0.91	61	empty
2	862	0.79	0.82	92	empty
3	116	0.78	0.97	28	G6Q
4	1158	0.76	0.79	109	G6Q, GLU
5	121	0.50	0.80	12	empty

Interfaces

1 interface between chains.

A–B · 2641 Å² buried · 50 hydrogen bonds · protein-protein

Compared structures

6ZMJ · Crystal structure of human GFAT-1 R203H · the same entry in another collection · chain A against A, TM-score 1.00
Q06210 · AlphaFold monomer V2.0 prediction for glutamine--fructose-6-phosphate aminotransferase… · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06210
Elsewhere: RCSB PDB 6ZMJ · PDBe 6ZMJ · UniProt Q06210

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