MolNFT v1 · #171784 · protein
Glic pentameric ligand-gated ion channel, pH 3
6ZGK · Proton-gated ion channel: “Glic pentameric ligand-gated ion channel, pH 3”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #171784 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZGK
- Type
- protein
- Length
- 1,535 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 31% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Proton-gated ion channel | protein | 307 | 31% helix, 29% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 860 | 0.85 | 0.87 | 116 | empty |
| 2 | 570 | 0.78 | 0.84 | 85 | empty |
| 3 | 352 | 0.74 | 0.85 | 58 | empty |
| 4 | 353 | 0.74 | 0.85 | 64 | empty |
| 5 | 482 | 0.72 | 0.81 | 64 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2077 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 2067 Ų buried · 7 hydrogen bonds · protein-protein
- A–E · 2063 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 2054 Ų buried · 7 hydrogen bonds · protein-protein
- D–E · 2052 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 6ZGK · PDBe 6ZGK · UniProt Q7NDN8
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