MolNFT v1 · #171754 · protein
High resolution structure of VEGF-a 12:107 crystallized in tetragonal form
6ZFL · Vascular endothelial growth factor a: “High resolution structure of VEGF-a 12:107 crystallized in tetragonal form”. X-ray diffraction, 1 ligand (PO4). MolNFT v1 #171754 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZFL
- Type
- protein
- Length
- 192 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vascular endothelial growth factor a
- UniProt
- P15692
- Ligands
- PO4
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 61% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| V, W | Vascular endothelial growth factor a | protein | 96 | 16% helix, 61% strand | P15692 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 3 copies · chains V, W
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · 4 copies · chains V, W
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- V–W · 1451 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6ZFL · High resolution structure of VEGF-A 12:107 crystallized in tetragonal form · the same entry in another collection · chain V against V, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15692
- Elsewhere: RCSB PDB 6ZFL · PDBe 6ZFL · UniProt P15692
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