GL1X · GenesisL1 explorer

MolNFT v1 · #171729 · protein

Flavourzyme leucine aminopeptidase a proenzyme

6ZEP: “Flavourzyme leucine aminopeptidase a proenzyme”. X-ray diffraction, 5 ligands (MAN, NAG, BMA), 2 pockets (best druggability 0.65). MolNFT v1 #171729 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
6ZEP
Type
protein
Length
341 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Leucine aminopeptidase a
EC
3.4.11.-
UniProt
Q2U1F3
Ligands
MAN, NAG, BMA, ZN, CL
Pockets
2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 17% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ALeucine aminopeptidase a (EC 3.4.11.-)protein34140% helix, 17% strandQ2U1F3

Ligands and binding sites

  • MAN · alpha-D-mannopyranose · sugar · 5 copies
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
  • BMA · beta-D-mannopyranose · sugar
  • ZN · Zinc ion · metal · 2 copies · chains A
  • CL · Chloride ion · ion · chains A
  • EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12110.650.8433ZN, CL
2580.340.7710empty

Modifications

Observed in the structure: 1 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

  • 6ZEP · Flavourzyme Leucine Aminopeptidase A proenzyme · the same entry in another collection · chain A against A, TM-score 1.00
  • Q2U1F3 · AlphaFold monomer V2.0 prediction for leucine aminopeptidase a (Q2U1F3) · a predicted model of the same protein · chain A against A, TM-score 0.99

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