MolNFT v1 · #171635 · protein

Hif prolyl hydroxylase 2 (PHD2/EGLN1) in complex with tert-butyl 6-(5- hydroxy-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-YL)NICOTINATE (IOX4)

6ZBN: “Hif prolyl hydroxylase 2 (PHD2/EGLN1) in complex with tert-butyl 6-(5…”. X-ray diffraction, 2 ligands (QEE, MN). MolNFT v1 #171635 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6ZBN
Type: protein
Length: 1,196 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q9GZT9
Ligands: QEE, MN

Structure

x-ray diffraction · 6 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	197	—	Q9GZT9
B	—	protein	202	—	Q9GZT9
C	—	protein	202	—	Q9GZT9
D	—	protein	200	—	Q9GZT9
E	—	protein	198	—	Q9GZT9
F	—	protein	197	—	Q9GZT9

Ligands and binding sites

QEE · ~{tert}-butyl 6-[5-oxidanyl-4-(1,2,3-triazol-1-yl) pyrazol-1-yl]pyridine-3-carboxylate · ligand · 6 copies · chains A, D, B, C, E, F
MN · Manganese (II) ion · metal · 6 copies · chains A, B, C, D, E, F
GOL · Glycerol · additive · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6ZBN · HIF Prolyl Hydroxylase 2 (PHD2/EGLN1) in complex with tert-butyl… · the same entry in another collection · chain F against F, TM-score 1.00
Q9GZT9 · AlphaFold monomer V2.0 prediction for egl nine homolog 1 (Q9GZT9) · a predicted model of the same protein · chain F against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZT9
Elsewhere: RCSB PDB 6ZBN · PDBe 6ZBN · UniProt Q9GZT9

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