MolNFT v1 · #17159 · protein
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
1OKC · ADP, ATP carrier protein heart isoform T1: “Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside”. X-ray diffraction, 4 ligands (PC1, CDL, LDM), 2 pockets (best druggability 0.75). MolNFT v1 #17159 on…
- PDB
- 1OKC
- Type
- protein
- Length
- 292 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ADP, ATP carrier protein heart isoform T1
- UniProt
- P02722
- Ligands
- PC1, CDL, LDM, CXT
- Pockets
- 2 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ADP, ATP carrier protein heart isoform T1 | protein | 292 | 78% helix, 0% strand | P02722 |
Ligands and binding sites
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 4 copies · chains A
- CDL · Cardiolipin · ligand · 3 copies · chains A
- LDM · 3-laurylamido-N,N'-dimethylpropylaminoxyde · ligand · 2 copies · chains A
- CXT · Carboxyatractyloside · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 809 | 0.75 | 0.79 | 53 | CXT |
| 2 | 70 | 0.33 | 0.75 | 10 | empty |
Compared structures
- 1OKC · structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside · the same entry in another collection · chain A against A, TM-score 1.00
- P02722 · AlphaFold monomer V2.0 prediction for ADP/ATP translocase 1 (P02722) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02722
- Elsewhere: RCSB PDB 1OKC · PDBe 1OKC · UniProt P02722
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.