MolNFT v1 · #17112 · protein
Yeast DNA topoisomerase I, N-terminal fragment
1OIS: “Yeast DNA topoisomerase I, N-terminal fragment”. X-ray diffraction, 3 pockets (best druggability 0.47). MolNFT v1 #17112 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1OIS
- Type
- protein
- Length
- 220 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA topoisomerase I
- EC
- 5.99.1.2
- UniProt
- P04786
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase I (EC 5.99.1.2) | protein | 220 | 31% helix, 19% strand | P04786 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.47 | 0.84 | 17 | empty |
| 2 | 115 | 0.38 | 0.74 | 20 | empty |
| 3 | 77 | 0.35 | 0.76 | 16 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04786
- Elsewhere: RCSB PDB 1OIS · PDBe 1OIS · UniProt P04786
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