Atomic-resolution structure of the coiled-coil dimerisation domain of human arc

Structure

x-ray diffraction · 2 distinct chains · 91% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · 2 copies · chains A, B
• CL · Chloride ion · ion · chains A
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 885 Ų buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

• 6YTU · Atomic-resolution structure of the coiled-coil dimerisation domain of human Arc · the same entry in another collection · chain A against A, TM-score 1.00
• Q7LC44 · AlphaFold monomer V2.0 prediction for activity-regulated cytoskeleton-associated protein… · a predicted model of the same protein · chain B against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q7LC44
• Elsewhere: RCSB PDB 6YTU · PDBe 6YTU · UniProt Q7LC44