UniProt Q7LC44
Activity-regulated cytoskeleton-associated protein (Q7LC44)
Activity-regulated cytoskeleton-associated protein (UniProt Q7LC44): 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q7LC44
- Protein
- Activity-regulated cytoskeleton-associated protein
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 4 · 1 record with a druggable one
Structures
9 records of Q7LC44 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6TN7 | Crystal structure of the human arc C-lobe | x-ray diffraction | B | — | — |
| 6TNQ | Crystal structure of the human Arc N-lobe bound to repeat 4 from GKAP | x-ray diffraction | A, C, E | ACE | 2 (best 0.48) |
| 6TNQ | Crystal structure of the human arc N-lobe bound to repeat 4 from gkap | x-ray diffraction | A, C, E | ACE | — |
| 6TQ0 | Crystal structure of the human arc N-lobe bound to repeat peptide 5 from gkap | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 6YTU | Atomic-resolution structure of the coiled-coil dimerisation domain of human arc | x-ray diffraction | A, B | ACE, CL | — |
| 7R1Z | C-terminal domain of hArc in complex with nanobodies H11 and C11, collapsed crystal form | x-ray diffraction | A | — | 2 (best 0.66) |
| 7R1Z | C-terminal domain of harc in complex with nanobodies H11 and C11, collapsed crystal form | x-ray diffraction | A | — | — |
| 8QF4 | Complex between N-lobe of Arc and nanobody H11 | x-ray diffraction | A | PO4 | — |
| Q7LC44 | AlphaFold monomer V2.0 prediction for activity-regulated cytoskeleton-associated protein (Q7LC44) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6TNQ chain A against the predicted model Q7LC44: TM-score 0.95, RMSD 0.70 Å
- 6TNQ chain A against the predicted model Q7LC44: TM-score 0.95, RMSD 0.70 Å
- 6TQ0 chain O against the predicted model Q7LC44: TM-score 0.94, RMSD 0.74 Å
- 6TQ0 chain G against the predicted model Q7LC44: TM-score 0.94, RMSD 0.77 Å
- 6TQ0 chain A against the predicted model Q7LC44: TM-score 0.94, RMSD 0.81 Å
- 6TQ0 chain C against the predicted model Q7LC44: TM-score 0.93, RMSD 0.82 Å
- 6TNQ chain E against the predicted model Q7LC44: TM-score 0.93, RMSD 0.82 Å
- 6TNQ chain E against the predicted model Q7LC44: TM-score 0.93, RMSD 0.82 Å
- 6TQ0 chain I against the predicted model Q7LC44: TM-score 0.93, RMSD 0.88 Å
- 6TQ0 chain M against the predicted model Q7LC44: TM-score 0.93, RMSD 0.95 Å
Elsewhere
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