MolNFT v1 · #171110 · protein
Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of CA2+
6YTQ · Calcium homeostasis modulator protein 4: “Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of CA2+”. Electron microscopy, 20 pockets (best druggability 0.78). MolNFT v1 #171110 on GenesisL1: 3D structure…
- PDB
- 6YTQ
- Type
- protein
- Length
- 5,874 residues
- Chains
- 22
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium homeostasis modulator protein 4
- UniProt
- Q5JW98
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | Calcium homeostasis modulator protein 4 | protein | 267 | 73% helix, 0% strand | Q5JW98 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 916 | 0.78 | 0.80 | 85 | empty |
| 2 | 885 | 0.78 | 0.81 | 86 | empty |
| 3 | 700 | 0.76 | 0.82 | 73 | empty |
| 4 | 1026 | 0.74 | 0.77 | 72 | empty |
| 5 | 1073 | 0.74 | 0.77 | 77 | empty |
Interfaces
56 interfaces between chains.
- I–J · 2171 Ų buried · 9 hydrogen bonds · protein-protein
- G–H · 2128 Ų buried · 6 hydrogen bonds · protein-protein
- R–S · 2100 Ų buried · 7 hydrogen bonds · protein-protein
- S–T · 2096 Ų buried · 8 hydrogen bonds · protein-protein
- M–N · 2093 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 44 disulfide (disulfide).
Compared structures
- 6YTQ · Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of Ca2+ · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JW98
- Elsewhere: RCSB PDB 6YTQ · PDBe 6YTQ · UniProt Q5JW98
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