UniProt Q5JW98
Calcium homeostasis modulator protein 4 (Q5JW98)
Calcium homeostasis modulator protein 4 (UniProt Q5JW98): 11 experimental structures and 1 predicted model on GenesisL1, 120 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5JW98
- Protein
- Calcium homeostasis modulator protein 4
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 120 · 7 records with a druggable one
Structures
12 records of Q5JW98 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YTK | Cryo-EM structure of a dimer of decameric human CALHM4 in the absence of Ca2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | 20 (best 0.79) |
| 6YTK | Cryo-EM structure of a dimer of decameric human CALHM4 in the absence of CA2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | — |
| 6YTL | Cryo-EM structure of a dimer of undecameric human CALHM4 in the absence of Ca2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | 20 (best 0.79) |
| 6YTL | Cryo-EM structure of a dimer of undecameric human CALHM4 in the absence of CA2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | — |
| 6YTO | Cryo-EM structure of a dimer of decameric human CALHM4 in the presence of Ca2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | 20 (best 0.79) |
| 6YTO | Cryo-EM structure of a dimer of decameric human CALHM4 in the presence of CA2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | — |
| 6YTQ | Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of Ca2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | 20 (best 0.78) |
| 6YTQ | Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of CA2+ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | — |
| 8RML | Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobody SbC4 | electron microscopy | A, B, K | — | 10 (best 0.80) |
| 8RMM | Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 | electron microscopy | A, B, K | — | 10 (best 0.80) |
| 8RMN | Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | 20 (best 0.78) |
| Q5JW98 | AlphaFold monomer V2.0 prediction for calcium homeostasis modulator protein 4 (Q5JW98) | predicted | A | — | — |
Experiment against prediction
- 8RMM chain K against the predicted model Q5JW98: TM-score 0.86, RMSD 2.56 Å
- 8RML chain K against the predicted model Q5JW98: TM-score 0.85, RMSD 2.63 Å
- 6YTL chain M against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
- 6YTL chain M against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
- 6YTL chain T against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
- 6YTL chain T against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
- 6YTL chain P against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
- 6YTL chain P against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
- 6YTL chain S against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
- 6YTL chain S against the predicted model Q5JW98: TM-score 0.85, RMSD 2.65 Å
Elsewhere
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