MolNFT v1 · #17105 · protein

Structure of lipase

1OIL: “Structure of lipase”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.66). MolNFT v1 #17105 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1OIL
Type: protein
Length: 640 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase
EC: 3.1.1.3
UniProt: P22088
Ligands: CA
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lipase (EC 3.1.1.3)	protein	320	38% helix, 19% strand	P22088

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	449	0.66	0.78	37	empty
2	422	0.64	0.77	39	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1OIL · Structure of lipase · the same entry in another collection · chain A against A, TM-score 1.00
P22088 · AlphaFold monomer V2.0 prediction for triacylglycerol lipase (P22088) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22088
Elsewhere: RCSB PDB 1OIL · PDBe 1OIL · UniProt P22088

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