MolNFT v1 · #1710 · protein
Structural analysis of phosducin and its phosphorylation-regulated interaction with transducin
1B9X · Protein (transducin): “Structural analysis of phosducin and its phosphorylation-regulated interaction with transducin”. X-ray diffraction, 1 ligand (GD), 5 pockets (best druggability 0.79). MolNFT v1 #1710 on GenesisL1: 3D…
- PDB
- 1B9X
- Type
- protein
- Length
- 577 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (transducin); Protein (phosducin)
- UniProt
- P62871, P02698, P20942
- Ligands
- GD
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (transducin) | protein | 340 | 7% helix, 46% strand | P62871 |
| B | Protein (transducin) | protein | 68 | 57% helix, 0% strand | P02698 |
| C | Protein (phosducin) | protein | 169 | 44% helix, 17% strand | P20942 |
Ligands and binding sites
- GD · Gadolinium atom · metal · 6 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 611 | 0.79 | 0.84 | 52 | empty |
| 2 | 436 | 0.68 | 0.80 | 61 | empty |
| 3 | 297 | 0.62 | 0.80 | 38 | empty |
| 4 | 63 | 0.43 | 0.82 | 20 | empty |
| 5 | 114 | 0.36 | 0.74 | 19 | GD |
Interfaces
3 interfaces between chains.
- A–B · 2627 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 1877 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 13 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1B9X · Structural analysis of phosducin and its phosphorylation-regulated interaction with… · the same entry in another collection · chain A against A, TM-score 1.00
- P20942 · AlphaFold monomer V2.0 prediction for phosducin (P20942) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain A against A, TM-score 0.96
- P02698 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62871
- Every structure of UniProt P02698
- Every structure of UniProt P20942
- Elsewhere: RCSB PDB 1B9X · PDBe 1B9X · UniProt P62871 · UniProt P02698 · UniProt P20942
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