Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with xtp, datp, dcmpnpp, mn and mg

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 0KX · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]cytidine · ligand · 2 copies · chains A, B
• CZF · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · ligand · 2 copies · chains A, B
• DTP · 2'-deoxyadenosine 5'-triphosphate · ligand · 2 copies · chains A, B
• MG · Magnesium ion · metal · 4 copies · chains A, B
• FE · Fe (III) ion · metal · 2 copies · chains A, B
• MN · Manganese (II) ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6YOM · Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dATP… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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• Every structure of UniProt Q9Y3Z3
• Elsewhere: RCSB PDB 6YOM · PDBe 6YOM · UniProt Q9Y3Z3