Human wtsting in complex with 2',2'-difluoro-3',3'-C-di-gmp

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 26% strand (DSSP).

Ligands and binding sites

• GGF · 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R}, 17~{R},18~{R})-17-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3, 12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$L^{5}, 12$L^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]-1~{H}-purin-6-one · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 6YDB · Human wtSTING in complex with 2',2'-difluoro-3',3'-c-di-GMP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt A0A2R3XZB7
• Elsewhere: RCSB PDB 6YDB · PDBe 6YDB · UniProt A0A2R3XZB7