MolNFT v1 · #170445 · protein
Engineered conjugation of lysine-specific molecular tweezers with exos derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding
6Y7T: “Engineered conjugation of lysine-specific molecular tweezers with exos derived peptidic inhibitor enhance…”. X-ray diffraction, 2 ligands (TWZ, NA). MolNFT v1 #170445 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Y7T
- Type
- protein
- Length
- 943 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31947, Q51451
- Ligands
- TWZ, NA
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F | — | protein | 230 | — | P31947 |
| D | — | protein | 10 | — | Q51451 |
| E | — | protein | 11 | — | Q51451 |
| K, P | — | protein | 231 | — | P31947 |
Ligands and binding sites
- TWZ · ExoSTWZ molecular tweezer · ligand · 2 copies · chains A, D, F, E
- NA · Sodium ion · metal · 5 copies · chains A, F, P, K
- GOL · Glycerol · additive · 2 copies · chains A, P
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6Y7T · Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic… · the same entry in another collection · chain P against P, TM-score 1.00
- P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain K against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31947
- Every structure of UniProt Q51451
- Elsewhere: RCSB PDB 6Y7T · PDBe 6Y7T · UniProt P31947 · UniProt Q51451
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