MolNFT v1 · #170365 · protein
Binary complex of 14-3-3 sigma (C38N) with the estrogen related receptor gamma (lbd) phosphopeptide
6Y58 · 14-3-3 protein sigma: “Binary complex of 14-3-3 sigma (C38N) with the estrogen related receptor gamma (lbd) phosphopeptide”. X-ray diffraction, 1 ligand (MG), 1 pocket (best druggability 0.47). MolNFT v1 #170365 on GenesisL1: 3D…
- PDB
- 6Y58
- Type
- protein
- Length
- 242 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein sigma; Estrogen related receptor gamma phosphopeptide
- UniProt
- P31947
- Ligands
- MG
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein sigma | protein | 236 | 80% helix, 0% strand | P31947 |
| P | Estrogen related receptor gamma phosphopeptide | protein | 6 | 0% helix, 0% strand | — |
Ligands and binding sites
- MG · Magnesium ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.47 | 0.85 | 16 | empty |
Interfaces
1 interface between chains.
- A–P · 512 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 6Y58 · Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (LBD)… · the same entry in another collection · chain A against A, TM-score 1.00
- P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31947
- Elsewhere: RCSB PDB 6Y58 · PDBe 6Y58 · UniProt P31947
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.