MolNFT v1 · #17021 · protein
Crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2 in complex with tad
1OG1 · T-cell ecto-ADP-ribosyltransferase 2: “Crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2 in complex with tad”. X-ray diffraction, 1 ligand (TAD), 3 pockets (best druggability 0.62). MolNFT v1 #17021 on…
- PDB
- 1OG1
- Type
- protein
- Length
- 223 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell ecto-ADP-ribosyltransferase 2
- EC
- 2.4.2.31
- UniProt
- P20974
- Ligands
- TAD
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-cell ecto-ADP-ribosyltransferase 2 (EC 2.4.2.31) | protein | 223 | 35% helix, 22% strand | P20974 |
Ligands and binding sites
- TAD · Beta-methylene-thiazole-4-carboxyamide-adenine dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.62 | 0.79 | 39 | TAD |
| 2 | 59 | 0.34 | 0.77 | 13 | empty |
| 3 | 51 | 0.28 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1OG1 · Crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2 in complex with tad · the same entry in another collection · chain A against A, TM-score 1.00
- P20974 · AlphaFold monomer V2.0 prediction for T-cell ecto-ADP- ribosyltransferase 2 (P20974) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20974
- Elsewhere: RCSB PDB 1OG1 · PDBe 1OG1 · UniProt P20974
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.