MolNFT v1 · #170183 · protein
Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1- [5-(6-chloro-1,1-dimethyl-3-oxo-isoindolin-2-yl)-3- PYRIDYL]ETHYL]METHANESULFONAMIDE
6XZ8: “Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1…”. X-ray diffraction, 2 ligands (HEC, O4T). MolNFT v1 #170183 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6XZ8
- Type
- protein
- Length
- 1,404 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P19099
- Ligands
- HEC, O4T
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 465 | — | P19099 |
| B | — | protein | 473 | — | P19099 |
| C | — | protein | 466 | — | P19099 |
Ligands and binding sites
- HEC · Heme C · ligand · 3 copies · chains A, B, C
- O4T · ~{N}-[(1~{R})-1-[5-(6-chloranyl-1,1-dimethyl-3-oxidanylidene-isoindol-2-yl)pyridin-3-yl]ethyl]methanesulfonamide · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6XZ8 · Structure of aldosterone synthase (CYP11B2) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P19099 · AlphaFold monomer V2.0 prediction for cytochrome P450 11B2, mitochondrial (P19099) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19099
- Elsewhere: RCSB PDB 6XZ8 · PDBe 6XZ8 · UniProt P19099
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