UniProt P19099
Cytochrome P450 11B2, mitochondrial (P19099)
Cytochrome P450 11B2, mitochondrial (UniProt P19099), EC 1.14.15.4, 1.14.15.5: 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 13 pockets. Binding sites, druggability and experiment against…
- UniProt
- P19099
- Protein
- Cytochrome P450 11B2, mitochondrial
- EC
- 1.14.15.4, 1.14.15.5
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 13 · 1 record with a druggable one
Structures
11 records of P19099 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4DVQ | Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4DVQ | Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4FDH | Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4FDH | Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4ZGX | Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 6XZ8 | Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1… | x-ray diffraction | A, B, C | HEC, O4T | — |
| 6XZ9 | Structure of aldosterone synthase (CYP11B2) in complex with… | x-ray diffraction | A, B, C | HEC, O4W | 13 (best 0.86) |
| 6XZ9 | Structure of aldosterone synthase (CYP11B2) in complex with 5-chloro… | x-ray diffraction | A, B, C | HEC, O4W | — |
| 7M8I | Human CYP11B2 and human adrenodoxin in complex with fadrozole | x-ray diffraction | A, B, C | FES, HEM, 0T3 | — |
| 7M8V | Human CYP11B2 in complex with LCI699 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | YSY, HEM | — |
| P19099 | AlphaFold monomer V2.0 prediction for cytochrome P450 11B2, mitochondrial (P19099) | predicted | A | — | — |
Ligands
- HEC · Heme C · in 3 records
- HEM · Protoporphyrin IX containing Fe · in 2 records
- O4W · 5-chloranyl-3,3-dimethyl-2-[5-[1-(1-methylpyrazol-4-yl)carbonylazetidin-3-yl]oxypyridin-3-yl]isoindol-1-one · in 2 records
- 0T3 · 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile · in 1 record
- FES · Fe2/s2 (inorganic) cluster · in 1 record
- O4T · ~{N}-[(1~{R})-1-[5-(6-chloranyl-1,1-dimethyl-3-oxidanylidene-isoindol-2-yl)pyridin-3-yl]ethyl]methanesulfonamide · in 1 record
- YSY · 4-[(4R,5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile · in 1 record
Experiment against prediction
- 7M8V chain E against the predicted model P19099: TM-score 0.99, RMSD 0.76 Å
- 7M8V chain B against the predicted model P19099: TM-score 0.99, RMSD 0.77 Å
- 7M8V chain F against the predicted model P19099: TM-score 0.99, RMSD 0.77 Å
- 7M8V chain L against the predicted model P19099: TM-score 0.99, RMSD 0.77 Å
- 7M8V chain G against the predicted model P19099: TM-score 0.99, RMSD 0.77 Å
- 7M8V chain J against the predicted model P19099: TM-score 0.99, RMSD 0.77 Å
- 7M8V chain I against the predicted model P19099: TM-score 0.99, RMSD 0.84 Å
- 4DVQ chain B against the predicted model P19099: TM-score 0.99, RMSD 0.84 Å
- 4DVQ chain B against the predicted model P19099: TM-score 0.99, RMSD 0.84 Å
- 7M8V chain K against the predicted model P19099: TM-score 0.99, RMSD 0.84 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.