MolNFT v1 · #170100 · protein
Structure of glutamate transporter homologue glttk in the unsaturated conditions - inward-inward-outward configuration
6XWO · PROTON/GLUTAMATE symporter, sdf family: “Structure of glutamate transporter homologue glttk in the unsaturated conditions - inward-inward-outward…”. Electron microscopy, 1 ligand (ASP), 18 pockets (best druggability 0.88). MolNFT v1…
- PDB
- 6XWO
- Type
- protein
- Length
- 1,280 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PROTON/GLUTAMATE symporter, sdf family
- UniProt
- Q5JID0
- Ligands
- ASP
- Pockets
- 18 · best druggability 0.88
Structure
electron microscopy · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | PROTON/GLUTAMATE symporter, sdf family | protein | 427 | 71% helix, 0% strand | Q5JID0 |
| C | PROTON/GLUTAMATE symporter, sdf family | protein | 426 | 66% helix, 0% strand | Q5JID0 |
Ligands and binding sites
- ASP · Aspartic acid · ligand · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 535 | 0.88 | 0.93 | 38 | empty |
| 2 | 641 | 0.66 | 0.75 | 61 | empty |
| 3 | 279 | 0.59 | 0.78 | 41 | empty |
| 4 | 93 | 0.58 | 0.87 | 22 | empty |
| 5 | 90 | 0.54 | 0.85 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1199 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1188 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1165 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6XWO · Structure of glutamate transporter homologue GltTk in the unsaturated conditions… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JID0
- Elsewhere: RCSB PDB 6XWO · PDBe 6XWO · UniProt Q5JID0
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