MolNFT v1 · #170014 · protein
Full-length lttr lysg from corynebacterium glutamicum with bound effector arg
6XTV · Lysine export transcriptional regulatory protein lysg: “Full-length lttr lysg from corynebacterium glutamicum with bound effector arg”. X-ray diffraction, 1 ligand (ARG), 6 pockets (best druggability 0.61). MolNFT v1 #170014 on…
- PDB
- 6XTV
- Type
- protein
- Length
- 575 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysine export transcriptional regulatory protein lysg
- UniProt
- P94632
- Ligands
- ARG
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lysine export transcriptional regulatory protein lysg | protein | 285 | 44% helix, 23% strand | P94632 |
| B | Lysine export transcriptional regulatory protein lysg | protein | 290 | 46% helix, 20% strand | P94632 |
Ligands and binding sites
- ARG · Arginine · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.61 | 0.82 | 36 | ARG |
| 2 | 284 | 0.59 | 0.78 | 30 | empty |
| 3 | 128 | 0.57 | 0.83 | 21 | empty |
| 4 | 107 | 0.48 | 0.81 | 19 | empty |
| 5 | 83 | 0.41 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1626 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6XTV · Full-length lttr lysg from corynebacterium glutamicum with bound effector arg · the same entry in another collection · chain A against A, TM-score 1.00
- P94632 · AlphaFold monomer V2.0 prediction for lysine export transcriptional regulatory protein… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P94632
- Elsewhere: RCSB PDB 6XTV · PDBe 6XTV · UniProt P94632
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