X-ray structure of the rhombohedral form of the lipase from thermomyces lanuginosa at 1.3 a resolution

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 24% strand (DSSP).

Ligands and binding sites

• LTV · 2-hydroxy-3-(octadecanoyloxy)propyl pentacosanoate · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
• PO4 · Phosphate ion · ion · 6 copies · chains A
• PG4 · Tetraethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 3 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 6XOK · X-ray structure of the rhombohedral form of the lipase from Thermomyces lanuginosa at 1.3… · the same entry in another collection · chain A against A, TM-score 1.00
• O59952 · AlphaFold monomer V2.0 prediction for lipase (O59952) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O59952
• Elsewhere: RCSB PDB 6XOK · PDBe 6XOK · UniProt O59952