MolNFT v1 · #169549 · protein
Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of fus
6XFM · RNA-binding protein fus: “Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of fus”. Electron microscopy, 2 pockets (best druggability 0.68). MolNFT v1 #169549 on GenesisL1: 3D structure, binding…
- PDB
- 6XFM
- Type
- protein
- Length
- 312 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-binding protein fus
- UniProt
- P35637
- Pockets
- 2 · best druggability 0.68
Structure
electron microscopy · 1 distinct chain · 0% helix, 64% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, 2, 3, 4, 5, 6, 7, 8 | RNA-binding protein fus | protein | 39 | 0% helix, 64% strand | P35637 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.68 | 0.84 | 40 | empty |
| 2 | 262 | 0.67 | 0.84 | 40 | empty |
Interfaces
18 interfaces between chains.
- 1–2 · 1578 Ų buried · 48 hydrogen bonds · protein-protein
- 6–7 · 1578 Ų buried · 48 hydrogen bonds · protein-protein
- 3–4 · 1575 Ų buried · 48 hydrogen bonds · protein-protein
- 2–3 · 1575 Ų buried · 48 hydrogen bonds · protein-protein
- 7–8 · 1574 Ų buried · 48 hydrogen bonds · protein-protein
Compared structures
- 6XFM · Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of FUS · the same entry in another collection · chain 1 against 1, TM-score 1.00
- P35637 · AlphaFold monomer V2.0 prediction for RNA-binding protein fus (P35637) · a predicted model of the same protein · chain 1 against A, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35637
- Elsewhere: RCSB PDB 6XFM · PDBe 6XFM · UniProt P35637
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